Michel Chrétien Selected Research

tetrapeptide carbamate

5/2005	Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
4/2005	Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
2/2004	Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.
6/2003	The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
3/2003	Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

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Michel Chrétien Research Topics

Disease

7	Neoplasms (Cancer) 10/2009 - 06/2002
6	Infections 01/2022 - 01/2007
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2008
4	Carcinogenesis 10/2009 - 04/2003
4	Atherosclerosis 10/2006 - 02/2004
3	Inflammation (Inflammations) 01/2021 - 01/2018
3	Vascular Remodeling 08/2004 - 03/2003
2	Malaria 01/2020 - 01/2018
2	Hyperinsulinism (Hyperinsulinemia) 01/2018 - 09/2015
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018 - 07/2015
2	Hypercholesterolemia 01/2014 - 09/2012
2	Infertility (Sterility) 10/2008 - 10/2006
2	Communicable Diseases (Infectious Diseases) 10/2008 - 10/2006
2	Neoplasm Metastasis (Metastasis) 11/2005 - 06/2002
2	Atherosclerotic Plaque (Atheroma) 05/2005 - 02/2004
2	Carcinoma (Carcinomatosis) 06/2003 - 04/2003
1	COVID-19 01/2022
1	Human Influenza (Influenza) 01/2022
1	Overweight 01/2021
1	Simpson-Golabi-Behmel syndrome 01/2021
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Hypertriglyceridemia 01/2021
1	Hyperlipidemias (Hyperlipidemia) 01/2018
1	Sepsis (Septicemia) 01/2018
1	Ebola Hemorrhagic Fever 01/2016
1	Insulin Resistance 09/2015
1	Glucose Intolerance 01/2015
1	Insulinoma 10/2013
1	Adenocarcinoma 10/2009
1	Breast Neoplasms (Breast Cancer) 10/2009
1	Chikungunya Fever 08/2008
1	Growth Disorders 06/2007
1	Parasitic Diseases (Parasitic Disease) 01/2007
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2006
1	Obesity 10/2006
1	Colonic Neoplasms (Colon Cancer) 11/2005
1	Virus Diseases (Viral Diseases) 01/2005
1	Alzheimer Disease (Alzheimer's Disease) 12/2004
1	Neointima 03/2003
1	Lassa Fever (Fever, Lassa) 03/2002

Drug/Important Bio-Agent (IBA)

7	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 09/2012 - 06/2002
6	CholesterolIBA 01/2022 - 01/2007
6	FurinIBA 08/2008 - 03/2003
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2002
5	tetrapeptide carbamateIBA 05/2005 - 03/2003
4	oxidized low density lipoproteinIBA 01/2021 - 01/2015
4	LDL Receptors (LDL Receptor)IBA 01/2021 - 09/2012
3	EnzymesIBA 02/2020 - 10/2006
2	isoquercitrinIBA 01/2022 - 01/2018
2	QuercetinIBA 01/2022 - 01/2016
2	LDL CholesterolIBA 01/2021 - 03/2014
2	Proprotein Convertase 9IBA 01/2021 - 01/2020
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2018 - 07/2015
2	FlavonoidsIBA 01/2016 - 01/2014
2	Glucose (Dextrose)FDA LinkGeneric 09/2015 - 01/2015
2	Peptide Hydrolases (Proteases)FDA Link 10/2009 - 08/2008
2	Membrane Glycoproteins (Membrane Glycoprotein)IBA 08/2008 - 03/2002
2	Messenger RNA (mRNA)IBA 11/2005 - 03/2003
2	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2005 - 08/2004
2	IntegrinsIBA 04/2005 - 02/2004
2	Integrin alphaVIBA 02/2004 - 03/2003
2	protease SIBA 06/2003 - 04/2003
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	FlavonolsIBA 01/2022
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021
1	Interleukin-1beta (Interleukin 1 beta)IBA 01/2021
1	InflammasomesIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 02/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 09/2015
1	ChylomicronsIBA 09/2015
1	Apolipoproteins B (ApoB)IBA 09/2015
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 09/2015
1	SteroidsIBA 07/2015
1	Estradiol (Delestrogen)FDA LinkGeneric 07/2015
1	ProinsulinIBA 10/2013
1	Insulin (Novolin)FDA Link 10/2013
1	Biological ProductsIBA 10/2009
1	anthraceneIBA 10/2009
1	SterolsIBA 10/2006
1	LipidsIBA 10/2006
1	Carrier Proteins (Binding Protein)IBA 11/2005
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 05/2005
1	Membrane-Associated Matrix MetalloproteinasesIBA 05/2005
1	SubtilisinIBA 04/2005
1	SARS-CoV spike glycoproteinIBA 01/2005
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2004
1	Amyloid beta-PeptidesIBA 12/2004
1	Vascular Endothelial Growth Factor CIBA 06/2003
1	Platelet-Derived Growth FactorIBA 04/2003
1	platelet-derived growth factor AIBA 04/2003
1	Metalloproteases (Metalloproteinases)IBA 06/2002
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2002

Therapy/Procedure

2	Therapeutics 04/2003 - 06/2002
1	Fat-Restricted Diet (Diet, Fat Restricted) 06/2007
1	Endarterectomy (Thromboendarterectomy) 02/2004
1	Subcutaneous Injections 06/2003